Tiny, soft, imperceptible wearable biosensors that can continuously monitor our body condition have the potential to revolutionize healthcare technologies. They are in urgent demand to realize the goal of personalized healthcare and digital medicine. In this project, we developed a series of next-generation wearable biosensors for advanced healthcare. These futuristic devices are developed based on the PERfECT chip, which is the world’s smallest wearable biosensing platform developed in Innovation Wing. In the next several years, we expect these wearables biosensors will help PERfECT-enabled spin-off biotech companies to revolutionize our current technologies in managing cardiovascular diseases, mental health, and diabetes.