Diabetes is one the most pressing chronic diseases in Hong Kong. There are about 0.7 million people in Hong Kong are suffering from diabetes. Realizing efficient blood glucose management is highly demanded to improve the patients’ healthcare. Currently, the blood glucose is mostly measured with the finger-stick method. However, the finger-stick method is painful and cannot continuously monitor the glucose level. This project develops a minimally invasive glucose biosensor by using a microneedle as sensor carrier and use HKU-developed “PERfECT wearable” platform for wireless data transmission. We hope this project could improve the health technology in Hong Kong to better serve the patients with diabetes.