COVID-19: Latent Clinical Phenotypes on Admission in Hong Kong across 2020
In the face of the COVID-19 pandemic, efforts in 2019 and 2020 have been devising immediate practices. However, limited knowledge on COVID-19 can lead to ineffective interventions and undesired consequences. To better understand the underlying mechanism of COVID-19, a population-based retrospective study was conducted.
It covered 7606 COVID-19 positive patients in Hong Kong across 2020. This large sample size brings great statistical power and generalizability to the results. It covers a broad disease severity spectrum and is representative of Hong Kong population.
The k-prototype clustering used here demonstrates an unprecedented strength to capture 86.6% deceased cases in one of the four clusters and identify most of the clinical characteristics of a poor prognosis without knowing them in the clustering process.
Upon further verification and investigation into these clusters, new understandings based on different clinical representations of COVID-19 will subsequently benefit disease prevention and the development of customized treatment protocols.